Description
The National Institutes of Health (NIH) is seeking scientific support services for the quality control of Induced Pluripotent Stem Cells (iPSCs) and the generation and characterization of organoids. The contractor will carry out two phases of work: quality assessment of 94 iPSC lines and generation and characterization of organoids from 26 of these iPSC lines. The contractor will provide deliverables including quality assessment reports, microscopy images, and scRNA-seq libraries.
• The contractor will assess the quality of 94 iPSC lines representing 2 lines for each of 47 different individuals from each of 9 karyotype groups.
• The contractor will generate and characterize organoids from 26 of these iPSC lines, involving organoid differentiation and growth characterization, assembloid formation, and MEA assay.
• The contractor will provide deliverables including quality assessment reports, microscopy images, and scRNA-seq libraries.
• The period of performance shall be no longer than 12 months from the date of contract award.