Olink Explorer >5400

The National Institutes of Health (NIH) is seeking a product that can measure approximately 5,400+ human proteins simultaneously in a single workflow. The product should use Proximity Extension Assay (PEA) with dual antibody recognition coupled to DNA barcoding and next-generation sequencing (NGS) readout. The product should have a high specificity, approximately 99.5%, and a dynamic range of about 10 orders of magnitude. The product should also have a low sample-volume requirement, requiring only 2 ul of plasma, serum, and other sample types. The key strengths of the product should include broad proteome coverage, excellent sensitivity for low-abundance circulating proteins, and a highly standardized platform. Some of the key features and benefits of the product include: • Very broad proteome coverage while maintaining antibody-based specificity • Excellent sensitivity for low-abundance circulating proteins (especially cytokines and signaling proteins) • Extremely low sample-volume requirement • Highly standardized platform, making it attractive for epidemiology and multi-omics studies