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U.S. Office of Science·United States of America

The Genesis Mission: Transforming Science and Energy with AI

Closes 12/17/2026$1M – $5MGrants Notice
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Description

The Department of Energy's (DOE) Office of Science is soliciting applications for the Genesis Mission, which aims to transform science and energy through the use of artificial intelligence (AI). The mission focuses on accelerating scientific discovery and research and development (R&D) workflows using novel AI models and frameworks. Interdisciplinary teams are encouraged to apply, addressing various topic areas such as advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy. Key aspects of the project include leveraging extensive scientific and data resources, integrating AI models and workflows into the American Science Cloud, and ensuring America's security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. • Topic areas include advanced manufacturing, biotechnology, critical materials, and more. • Applications are open for Phase I small team and Phase II large team projects. • The project aims to advance the DOE's mission through AI-driven scientific discovery and R&D. • Integration into the American Science Cloud is a potential outcome for successful projects. • A wide range of focus areas are available for applicants to choose from, each with specific goals and objectives. • The Genesis Mission seeks to ensure America's security and prosperity by addressing key challenges.

Attached files

Contact

Michael S Zarkin(Grants Management Specialist)

[email protected]

(301) 903-4946

Key dates

Opened
3/17/2026
Closes
12/17/2026
Duration
9 months for Phase I; 3 years for Phase II

Last updated

Details

Type
Grants Notice
Industry
Energy and Utilities
NAICS
541720
Solicitation №
DE-FOA-0003612

Budget estimate

$1,000,000 – $5,000,000

Given the estimated funding for this opportunity is $293,760,000, with an award ceiling of $16,000,000 and an award floor of $500,000, the budget for a single award could range widely. However, considering the complexity and the scope of the projects, which involve interdisciplinary teams and the integration of AI into scientific workflows, a reasonable estimate for a project could be between $1,000,000 to $5,000,000. This estimation takes into account the need for significant resources to leverage extensive scientific and data resources, develop novel AI models, and ensure integration into the American Science Cloud. The actual budget could vary based on the project's specific requirements, the team's expertise, and the project's duration.

AI estimate from the solicitation

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