Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)

This funding opportunity announcement (FOA) encourages applications that propose to develop studies leading to a broad understanding of the natural history of disorders that already do or could potentially benefit from early identification by newborn screening. The goal is to facilitate appropriate interventions for infants identified by newborn screening. Key aspects of the project include: * Developing studies to understand the natural history of disorders * Identifying genotype-phenotype correlations to predict clinical course * Identifying modifying genetic, epigenetic, or environmental factors to enhance understanding of clinical outcomes * Providing accurate diagnosis, understanding genetic and clinical heterogeneity, and identifying underlying mechanisms * Potentially preventing, managing, and treating symptoms and complications * Providing children and their families with needed support and predictive information about the disorder. Some of the key eligibility criteria include: * Alaska Native and Native Hawaiian Serving Institutions * Asian American Native American Pacific Islander Serving Institutions * Eligible Agencies of the Federal Government * Faith-based or Community-based Organizations * Hispanic-serving Institutions * Historically Black Colleges and Universities * Indian/Native American Tribal Governments * Non-domestic (non-U.S.) Entities * Regional Organizations * Tribally Controlled Colleges and Universities * U.S. Territory or Possession