Request for Information: Biomolecule Purification

The Defense Advanced Research Projects Agency (DARPA) is seeking information on novel methods for the purification of large complex molecules. The goal is to create a universal purification platform capable of separating and recovering multiple large and complex molecules with high specificity, purity, and yield from complex feedstock. This platform would decrease the time and complexity of purification and eliminate the need for current state-of-the-art multistep chromatography processes. Some key points to consider include: • The current advances and challenges in the purification of biologically-produced proteins and other critical biologically-produced molecules • New operational capabilities enabled by novel purification approaches • Single-step and tunable purification platforms for large molecules generated by manufacturing processes • Theoretical and simulation discussions of novel purification methods • Development strategies for novel purification approaches • Estimated time to availability and risk assessment of novel purification methods