Special Notice for Technology InteGrator and AcceleratoR (TIGAR)

The Advanced Research Projects Agency for Health (ARPA-H) is publishing a Special Notice to alert the scientific community to a newly approved solicitation and notify potential proposers of an associated webinar. The Technology InteGrator and AcceleratoR (TIGAR) Exploratory Topic will support the evaluation of early-stage, high-risk, high-impact concepts to advance the development of temperature-flexible preservation solutions for complex tissues and organs. The program aims to accelerate the development of transformative preservation concepts that unlock new capabilities in regenerative medicine, expand equitable access to advanced therapies, and reduce dependence on animal models. • The TIGAR Exploratory Topic will have two intake groups for the submission of well-scoped, early-stage, high-risk/high-impact bio-preservation concepts. • Proposers must demonstrate progress towards functional preservation of either entire structures or one cubic centimeter volumes of tissue for ≥30 days, at practical temperatures, by the end of the performance period. • The total ARPA-H funding requested shall not exceed $2 million USD over the 18-month period of performance. • Preferred demonstration tissue systems are those that are currently challenging to biobank or stockpile, such as organoids, donated tissues, whole organs, organ sub-structures, vascularized allografts, and engineered tissues.