Description
The National Institute on Aging (NIA) seeks a single contractor to perform DNA methylation profiling and epigenetic age analysis on 320 previously extracted murine DNA samples using the Illumina Mammal320K array and Horvath epigenetic clock algorithms. The contractor will receive the samples, conduct bisulfite conversion, run the array, perform quality control, generate raw data, apply aging algorithms, and deliver processed datasets and analysis reports electronically. The work is non‑competitive and will be performed under a firm‑fixed‑price contract.
• Scope: Processing of 320 murine DNA samples (80 blood, 240 tissue from 8 organs)
• Services: Bisulfite conversion, array hybridization, scanning, QC, bioinformatic analysis, age‑estimate calculation, report generation
• Deliverables: Raw array files, QC documentation, age‑estimate tables, bioinformatic output, comparative data tables across three oxygen‑exposure conditions
• Timeline: Approximately 6 weeks from receipt of samples to final data delivery
• Location: Samples shipped to contractor; deliverables submitted electronically to NIH/NIA, Baltimore, MD
• Funding: Firm‑fixed‑price, non‑competitive award (sole source)