Assay Service for assessing ADME properties and in vivo PK properties with the selected vendor. ENAMINE US INC

The National Institutes of Health’s Section on Medicinal Chemistry (SMC) seeks a qualified vendor to provide chemical reagent (assay) development and laboratory testing services. The scope includes performing a suite of ADME (Absorption, Distribution, Metabolism, Excretion) assays—such as Caco‑2 permeability—and conducting an in‑vivo pharmacokinetic (PK) study in C57BL/6 mice to evaluate oral availability of novel molecular entities. Deliverables are assay data that support structure‑activity relationship (SAR) optimization and de‑risking decisions for drug development. • Service type: assay development, in‑vitro ADME testing, in‑vivo PK study in mice. • Target organism: C57BL/6 mouse model. • Required assays: Caco‑2 permeability plus other grouped ADME assays. • Outcome: quantitative PK parameters and permeability data to inform lead optimization. • Vendor must have expertise in medicinal chemistry support and animal study compliance.