NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage UG3/UH3 phased cooperative agreement research applications to plan and implement behavioral and social intervention clinical trials related to dental, oral, or craniofacial conditions. The award will initially support a milestone-driven planning phase for up to 2 years, with possible transition to a clinical trial implementation phase of up to five years. Key aspects of the project include: • Developing and testing behavior change interventions • Conducting small-scale data collection to assess feasibility and acceptability of planned interventions • Creating essential documents such as the final clinical protocol, intervention manual, and data management system • Recruiting and retaining participants • Ensuring safety and operational oversight The UG3/UH3 application must be submitted as a single application, and only projects that meet scientific milestones and feasibility requirements may transition to the UH3 phase.