Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R33 Clinical Trial Required)

This NIH Notice of Funding Opportunity (NOFO) seeks applications for multi‑site feasibility clinical trials of mind‑and‑body interventions (e.g., meditation, yoga, acupuncture, music) aimed at restoring whole‑person health. The award is a cooperative agreement (R33) with a ceiling of $500,000. Projects must involve at least two geographically distinct sites, demonstrate fidelity of intervention delivery, assess recruitment/retention, collect comprehensive clinical and mechanistic data, and explore correlations between emotional‑well‑being mechanisms and health outcomes using the Whole Person Health Index. Eligible applicants include a broad range of public, nonprofit, and for‑profit entities (excluding foreign organizations). The anticipated award date is July 13 2027, with project start around July 20 2027. • Multi‑site feasibility trial (≥2 sites) of mind‑body therapies • Focus on whole‑person health restoration and emotional‑well‑being mechanisms • Required use of Whole Person Health Index as primary outcome • Cooperative agreement (R33) with up to $500 K funding ceiling • Open to U.S. public, nonprofit, and for‑profit entities (no foreign applicants) • Submission deadline: 11 / 16 / 2029; award expected 07 / 13 / 2027.