Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)

The National Institutes of Health (NIH) is soliciting applications for full-scale hybrid effectiveness-implementation trials to test the effectiveness of mental health interventions. The purpose of this funding opportunity is to support clinical trials that address significant problems and have the potential to inform practice. The trials should be adequately powered to definitively answer primary research questions and should examine questions regarding mediators and moderators of effects. • The funding opportunity supports trials that test the effectiveness of optimized therapeutic and preventive interventions for use in community and practice settings. • The funding opportunity also supports trials that evaluate the effectiveness of patient-, provider-, organizational-, or systems-level services interventions to improve access, continuity, quality, equity, and/or value of mental health services. • The collaborative R01 mechanism provides support for multisite trials when two or more sites are necessary for completion of the trial. • The funding opportunity is intended to support trials that explicitly address whether the intervention engages the target(s)/mechanism(s) presumed to underlie the intervention effects.