NIAMS Clinical Trial Implementation Cooperative Agreement

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Clinical Trial Cooperative Agreement Program. This program will support investigator-initiated, single or multi-site, interventional clinical trials within the mission areas of the institute. The program will have two phases, with the first phase allowing investigators to prepare for the trial and the second phase beginning the trial. • The program will support trials that are hypothesis-driven and have the potential for high clinical impact within the research mission of NIAMS. • Investigators who have completed all necessary preparation through other means may apply for a NIAMS Cooperative Agreement Clinical Trial. • The program will have a two-phase approach, with the first phase allowing investigators to prepare for the trial and the second phase beginning the trial. • Transition to the second phase will be dependent upon completion of the phase 1 milestones proposed by the investigator and approved by NIAMS. • NIAMS expects trials to be hypothesis-driven and have the potential for high clinical impact within the research mission of NIAMS.