Collaborative Program Grant for Interdisciplinary Teams (RM1 Clinical Trial Optional)

The NIH Collaborative Program Grant (RM1) funds interdisciplinary teams of 3‑6 investigators to pursue ambitious, single‑goal research projects that cannot be achieved by individual efforts. Teams must demonstrate strong synergy, integrated collaboration, and may optionally include a clinical trial component (RM1). The program supports a wide range of health‑related research areas, as reflected in its numerous CFDA listings, and is open to a broad spectrum of U.S. public, private, and nonprofit entities (excluding foreign sub‑awards). Funding is discretionary, with no cost‑sharing required, and award amounts are not capped. • Eligible applicants: State, local, tribal, higher‑education, for‑profit (non‑SB), nonprofit (501(c)(3) and others), and small businesses. • Team composition: 3‑6 PDs/PIs, each bringing complementary expertise. • Application windows: Multiple cycles; the latest deadline is 11/26/2029. • Estimated award start: 12/01/2027; review cycles begin March‑July 2027 onward. • No foreign sub‑awards allowed; all work must be performed by U.S. entities. • Funding instrument: Grant (RM1 – Research Project with Complex Structure). • Contact for scientific questions: NIGMS‑[email protected]. • Submission via ASSIST/eRA Commons; assistance via eRA Service Desk.