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U.S. Department Of Health And Human Services·Maryland

NOI- Preparation of chemical compounds needed for a Janus kinase 2 (JAK2) enzyme project

Closes 5/4/2026$100k – $500kSole Source
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Description

The National Institutes of Health (NIH) is seeking a contractor to synthesize two chemical compounds, 4-amino-N,N-dicyclopropyl-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide and N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, for use in brain cancer research. The contractor will be responsible for synthesizing the compounds at a 95% purity level and delivering them to the NIH. The contract will be for a period of two months after receipt of the approved order. * Synthesis of the two chemical compounds at a 95% purity level * Delivery of the compounds to the NIH * Provision of biweekly reports on progress * Compliance with all applicable laws and regulations

Attached files

Contact

Jaddua Johnston(Contract Specialist)

[email protected]

(240) 569-0006

Key dates

Opened
4/23/2026
Closes
5/4/2026
Duration
2 months

Last updated

Details

Type
Sole Source
Industry
Chemical Manufacturing
NAICS
325199
Solicitation №
75N98026Q00251

Budget estimate

$100,000 – $500,000

Based on the information provided, it is difficult to estimate the exact budget for this opportunity. However, considering the complexity of the synthesis and the requirements for purity, it is likely that the budget will be in the range of $100,000 to $500,000. This estimate is based on the assumption that the contractor will need to invest significant resources in terms of personnel, equipment, and materials to synthesize the compounds and deliver them to the NIH. Additionally, the budget may be influenced by the novelty and importance of the research, as well as the potential for future collaborations and funding opportunities.

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