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U.S. Department Of Energy·Ohio

TECHNOLOGY LICENSING OPPORTUNITY: SignalGen

Closes 3/22/2027$100k – $500kRequest for Expression of Interest
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Description

SignalGen is a generative‑AI platform developed by Los Alamos National Laboratory that predicts the optimal signal peptide for a given protein, organism, and target cellular compartment. The technology enables biotech, pharmaceutical, and synthetic‑biology companies to improve protein expression yields and streamline development cycles. Licensing is offered on a non‑exclusive or exclusive basis, with no external development services requested. • AI‑driven prediction of signal peptides for any protein (human or non‑human) • Considers protein sequence, desired subcellular location, and organism • Natural‑language interface eliminates need for coding • Demonstrated ~90 % prediction accuracy (TRL 3) • Applicable to therapeutic protein development, vaccines, drug discovery, biomanufacturing, protein engineering, synthetic biology, industrial biotech, and basic molecular‑biology research • Patent‑pending technology (U.S. Patent pending, LA‑UR‑26‑27860) • Licensing contacts through LANL’s Technology Transfer office

Attached files

Contact

Satya Srinivasan

[email protected]

Key dates

Opened
9/22/2026
Closes
3/22/2027

Last updated

Details

Type
Request for Expression of Interest
Industry
Information Technology and Software Development
NAICS
541714
Solicitation №
S-195368

Budget estimate

$100,000 – $500,000

Based on typical technology licensing arrangements for AI‑driven biotech tools, fees often range from a low‑to‑mid‑six‑figure upfront license payment plus annual royalties or milestone payments. For a platform like SignalGen, a reasonable estimate would be $100,000‑$500,000 in total expected revenue over the first few years, depending on scope (exclusive vs. non‑exclusive) and the size of the licensee’s commercial pipeline.

AI estimate from the solicitation

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