Small Instruments and Modern Equipment for Shared-use Biomedical Research Facilities and Resources (S15 Clinical Trial Not Allowed)

This Funding Opportunity Notice (NOFO) from the NIH’s Office of Research Infrastructure Programs invites shared‑use biomedical research facilities (core labs, biorepositories, model‑resource centers, etc.) to apply for funding to purchase new small instruments or modern equipment. The intent is to modernize and improve the efficiency of shared research resources, especially for devices that generate physical, chemical, or biomaterial outputs rather than purely digital data. Funding is limited to 16 awards, with individual award amounts ranging from $25,000 to $350,000, and a total estimated funding pool of $5 million. The grant cannot be used for highly specialized instruments, building‑level infrastructure, or clinical trial (S15) activities. Eligible applicants include a broad spectrum of public, private, tribal, and nonprofit entities. Key dates: posting 08/24/2026, application deadline 09/27/2027, award 07/18/2028, project start 07/25/2028. • Target audience: shared‑use biomedical research facilities (academic, government, nonprofit, tribal, etc.) • Funding purpose: purchase of small, emerging‑technology instruments that produce non‑digital outputs • Award size: $25 k–$350 k per award (up to 16 awards) • Total program ceiling: $5 M • Ineligible: highly specialized instruments, building‑level infrastructure, S15 clinical‑trial equipment • Application deadline: 27 Sep 2027 • Estimated award date: 18 Jul 2028