Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)

This funding opportunity aims to support high-risk clinical trials for the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear. Proposed projects should focus on improving the resolution of current imaging techniques or developing new imaging techniques that can visualize inner ear structures in vivo with significantly greater detail and accuracy than currently possible. The research supported in response to this RFA is expected to significantly advance the ability to visualize auditory and vestibular components in detail in awake patients in a clinical setting using non-invasive techniques. Key aspects of the project include: • Developing new imaging techniques or improving the resolution of current techniques • Visualizing dynamic elements, such as hair cells, otoliths, membranes, ions, and vasculature • Developing new imaging probes or contrast agents to enhance visualization of inner ear structures • Using a multidisciplinary team approach to take advantage of the expertise of each team member • Proposing studies in humans to develop, advance, or test the needed technology