Hive 2.0: Expansion of FDA ARGOS

The U.S. Food and Drug Administration (FDA) is seeking to modify an existing contract with DNA HIVE to expand the current repository of genetic sequence information under the ARGOS database. The contractor will provide research and development services, including biological and bioinformatic research, to expand the ARGOS system. The expansion aims to increase the number of sequences and organisms that are validated in the ARGOS system, resulting in a marked increase in the utility of the ARGOS database. • The contractor will deploy, configure, and launch an ARGOS instance running on a newer version of H2O. • The contractor will develop, adopt, and deploy AI and NGS Bioinformatics tools for various tasks, including evaluation of epigenetic-based pathogen detection diagnostics products and assembly of new virus genomes. • The contractor will deliver regulatory-grade high-quality reference datasets and provide system installation, maintenance, user documentation, and operation manuals. • The contractor will integrate FDA into the ARPA-H FEAST network to provide RWD access.