Medicinal Chemistry Support Program for Therapeutic Development

The National Institutes of Health (NIH) intends to modify an existing contract for medicinal chemistry support services to increase the maximum value by $30,145,159. The contract is for the development of therapeutics within the mission of the National Institute on Neurological Disorders and Stroke (NINDS) and the NIH Blueprint Neurotherapeutics Network (BPN). The contractor will provide medicinal chemistry services, including project management, compound logistics, synthesis, computational chemistry, and in vitro ADME studies. The contract has two performance areas: Tech Transfer, Storage Handling and Distribution, Access Training and IT Security Relevant to Existing Compound Repository, and Medicinal Chemistry Support. Some key points about this opportunity include: • The contract has a 10-year ordering period from March 16, 2018, to March 15, 2028. • The contractor must have the capacity to continue its work on existing and ongoing projects simultaneously in the three chemistry stages: exploratory, hit-to-lead, and lead optimization. • The contractor must be able to rapidly scale up or down the number of staff dedicated to the contract, depending on the number of projects underway at any given time. • The contract includes services such as project planning, project management, design, procurement, and milligram-scale synthesis of chemical analogs, multi-gram and scale-up synthesis for testing in animal models, in vitro ADME and toxicology testing for lead optimization, compound registration, and data entry.