Medicinal Chemistry Support Program for Therapeutic Development (MCSP)

The National Institute on Neurological Disorders and Stroke (NINDS) and the NIH Blueprint Neurotherapeutics Network (BPN) are seeking information from qualified vendors to support the Medicinal Chemistry Support Program for Therapeutic Development (MCSP). The program requires a full-service, turn-key medicinal chemistry operation for the development of therapeutics, including project management and reporting, compound logistics, synthesis, computational chemistry, and in vitro ADMET studies. Vendors must demonstrate experience and capability to conduct 1-10 projects simultaneously in the three chemistry stages: exploratory, hit-to-lead, and lead optimization. Key aspects of the program include: • Medicinal chemistry services, including SAR analysis and design, synthesis, and in vitro ADMET studies • Project management and reporting • Compound logistics, including storage and shipping • Computational chemistry and Computer-Aided Drug Discovery (CADD) • Capability to rapidly scale up or down the number of staff dedicated to the MCSP contract • Experience and success in providing a flexible medicinal chemistry support program • Demonstrated capability for productive collaborations with organizations and researchers involved in therapeutic development