Description
The National Institutes of Health (NIH) is seeking a non‑competitive, firm‑fixed‑price contractor to perform DNA methylation profiling and epigenetic age analysis on 320 pre‑extracted murine DNA samples using the Illumina Horvath Mammal320K array and established Horvath clock algorithms. The contractor will receive the samples, conduct bisulfite conversion, run the methylation arrays, perform quality control, generate raw data, compute biological age estimates, and deliver comprehensive bioinformatic and statistical reports. Deliverables must be submitted electronically within roughly six weeks of sample receipt.
• Process 320 murine DNA samples (80 longitudinal blood‑derived, 240 tissue‑derived) with Illumina Mammal320K arrays.
• Perform bisulfite conversion, array scanning, QC, and apply Horvath epigenetic clock to produce age estimates.
• Provide raw data files, QC documentation, computed ages, and summarized analyses comparing control, intermittent hypoxia, and intermittent hyperoxia groups across adult and longest‑lived cohorts.
• All work must be completed on a non‑competitive basis, with the contractor receiving the DNA samples and associated metadata from NIH and delivering final results electronically to NIH/NIA in Baltimore, MD.