FDA shear flow instrument system

The U.S. Food and Drug Administration (FDA) is seeking a BioFlux 200+ or equal flexible shear flow system to evaluate human platelets and red blood cells in their physiological environment. The system should be able to mimic in vivo conditions, be compatible with existing Nikon Eclipse Model TE200-U inverted microscope, and provide uniform and reproducible pressures for the cells to move in microfluidic channels. The system should also be capable of reproducible and repeatable shear flow rates, pulsatile flow to simulate heartbeat, and have environmental control at the sample level with dual gas input options. Some key features of the required system include: * A stand-alone shear flow system, new and not refurbished * Compatible with existing Nikon Eclipse Model TE200-U inverted microscope * Comprehensive and closed system capable of addressing multiple types of cell-related scientific questions * Uniform and reproducible pressures for the cells to move in microfluidic channels * Reproducible and repeatable shear flow rates to be programmed between 0-200 dynes/cm2 * Capable of single and bi-directional flow * Pulsatile flow to simulate heartbeat up to 120/bps * Environmental control at the sample level with dual gas input options * Throughput of up to 24 individual experiments per plate depending on configuration * 24, 48, and 96-well plate configurations * Two (2) shear flow input experiments for gradient based image analysis from dual inputs * Include a computer workstation to run operating software * Include a minimum one-year full manufacturer’s warranty