Mouse PK/PD Study Services for NNMT Inhibitors

The National Institutes of Health (NIH) is seeking a contractor to provide mouse PK/PD study services for NNMT inhibitors. The contractor will perform single-dose oral and intravenous studies in mice, collect biological samples, and quantify concentrations of the test article and 1-methyl nicotinamide using established bioanalytical methods. The contractor will also calculate standard pharmacokinetic parameters and provide the resulting data and final study report. The period of performance shall be up to three months from receipt of the purchase order, and the contractor shall provide the following deliverables: plasma concentration data, concentration-versus-time tables and curves, calculated PK parameters, and a final study report. • The contractor shall provide commercially available nonclinical study services necessary to complete the required mouse PK/PD studies. • The contractor shall perform single-dose mouse studies for each of 10 test articles. • The contractor shall quantify concentrations of the test article and 1-methyl nicotinamide using established bioanalytical methods. • The contractor shall calculate standard pharmacokinetic parameters and provide the resulting data and final study report. • The contractor shall maintain the confidentiality of all Government-furnished information and all data generated under this order.