National Biomedical Research Centers (P50 Clinical Trial Optional)

The National Institutes of Health (NIH) is seeking applications for the National Biomedical Research Centers (NBRCs) program. The NBRCs are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. The program emphasizes the development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. • The NBRCs will function as centers of innovation in fundamental science and translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. • The program allows clinical trials only as human-based New Approach Methodologies (NAMs), where applicable. • The NIH intends for the NBRCs to become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models. • The program is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies.