Preparedness for and Prevention of Severe Disease and Sequelae of Respiratory Viruses and Other Respiratory Pathogens

The Centers for Disease Control and Prevention (CDC) is seeking applications for research to prevent and mitigate severe respiratory illness and related complications. The purpose of this notice of funding opportunity (NOFO) is to support research to study the epidemiology, prevention, treatment, and outcomes of severe disease and complications of infections with respiratory viruses and other respiratory pathogens. Specific projects may include a focus on immunity and protection of people at high-risk, detection and prevention of respiratory pathogens, evaluation of effectiveness of prevention products, assessment of uptake and use of treatment products, and description of sequelae and outcomes related to respiratory illness. Some key aspects of this opportunity include: • Research on the epidemiology, prevention, treatment, and outcomes of severe disease and complications of respiratory viruses and other respiratory pathogens • Focus on immunity and protection of people at high-risk, including pregnant women and infants, children, older adults, and people with immunocompromising and other high-risk conditions • Detection and prevention of respiratory pathogens, including respiratory viruses and other respiratory pathogens • Evaluation of effectiveness of prevention products, including vaccines and monoclonal antibodies • Assessment of uptake and use of treatment products, including antiviral drugs, antimicrobials, and immunomodulators • Description of sequelae and outcomes related to respiratory illness up to 2 years after infection