Improving Protection against Influenza and Other Respiratory Pathogens: the US Flu VE Network

The purpose of this notice of funding opportunity (NOFO) is to continue the work of the US Influenza Vaccine Effectiveness (Flu VE) Network. Influenza and other respiratory pathogens are important causes of morbidity, mortality, and healthcare burden across the age spectrum. This network provides evidence needed to improve the effectiveness of influenza and other respiratory pathogen vaccines. The proposed work under this NOFO includes annual VE and correlates of protection surveillance, electronic acute respiratory illness and VE surveillance, household transmission research studies, and immunogenicity research studies. • The anticipated award number for each component is: five for Component A (VE and correlates of protection), one for Component B (Coordination and surge capacity), two for Component C (Household transmission studies), and three for Component D (Immunogenicity studies). • Applicants are required to apply for either Component A or B, but not both. • If an applicant applies for Component A, they may also apply for optional Components C or D, or both. • If an applicant applies for Component B, they may also apply for optional Component D. • The estimated funding for this opportunity is $75,250,000, with an award ceiling of $3,550,000 and an award floor of $1,350,000.