Selective Precision Targeting (SPoT)

The National Center for Advancing Translational Science (NCATS) is seeking to establish a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). The initiative goals are to: • Optimize specific targeting of nanoparticle therapeutics to the target organ/cell of interest • Assess biodistribution and off-target effects using a multi-organ microphysiological system • Provide evidence of functional cargo activity • Determine optimal route of administration The grant authorities that allow NCATS to forecast this opportunity are as follows: 42 U.S. Code § 287a - Cures Acceleration Network.