Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed)

The National Institutes of Health (NIH) is seeking applications for research on undruggable target classes within intractable human disease. Applicants will identify a human disease relevant undruggable target class and develop a method or agent that is selective for one or more targets within that target class. The goal of this research is to demonstrate innovative strategies to modulate targets that cannot be addressed by established therapeutic types, furthering the development of methods and/or agents selective for undruggable target classes. • The research will focus on undruggable target classes within intractable human disease. • Applicants will develop a method or agent that is selective for one or more targets within the target class. • The research will demonstrate innovative strategies to modulate targets that cannot be addressed by established therapeutic types. • The goal is to further the development of methods and/or agents selective for undruggable target classes. • The proposed project should serve as a use case that demonstrates modulation of a traditionally undruggable target, but that also serves as a proof of concept for a larger study and/or technology development that could be applied to the undruggable target class as a whole.