Toxicity of Resin 3-D Printing Emissions: Phase 1

The Centers for Disease Control and Prevention (CDC) intends to award a sole source firm fixed price purchase order to the Department of Orthopaedics, School of Medicine, West Virginia University (WVU) for the procurement of the measurement of toxicity associated with resin 3-D printing emissions. The vendor will be required to determine the dose-response relationship of pulmonary inflammation and systemic toxicity induced by VP printing emissions in mice and determine the sensitization potential following inhalation exposure to VP printing emissions in mice. • The vendor must have unique training, a unique exposure system, and the ability to rapidly transfer samples with limited stability to NIOSH Morgantown. • The vendor must be local to permit the transfer of equipment for the study period and to allow for frequent coordination, monitoring, and technical adjustments by NIOSH staff. • The vendor will collect biological specimens for NIOSH to analyze, and these samples are extremely sensitive, requiring prompt transfer and processing at NIOSH.