Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)

This opportunity supports applications to develop and implement a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials, including efficacy, comparative effectiveness, pragmatic, and/or implementation research clinical trials. The trials must be relevant to the research mission of the NHLBI and meet the NIH definition of a clinical trial. The key aspects of this opportunity include: • Developing and implementing a Clinical Coordinating Center for multi-site clinical trials • Supporting investigator-initiated clinical trials • Focusing on research relevant to the NHLBI's mission • Meeting the NIH definition of a clinical trial • Utilizing a bi-phasic, milestone-driven cooperative agreement mechanism of award • Requiring a collaborating Data Coordinating Center application to be submitted on the same application due date