Ultra-High Pressure Liquid Chromatography Quadrupole Time of Flight Mass Spectrometer

The National Institute of Standards and Technology (NIST) is seeking information from potential sources for an Ultra-High Pressure Liquid Chromatography Quadrupole Time of Flight Mass Spectrometer. The system should include a benchtop QTOF mass spectrometer and an UHPLC system, with specific requirements such as electrospray ionization (ESI) source, ability to interface with a direct analysis in real time (DART) source or an atmospheric pressure photoionization (APPI) source, and a syringe pump for automated infusion. The system should also have a PC-based data system, instrument control and data acquisition software, and a monitor. Key features of the system include: • The ability to detect 1 pg Reserpine at signal-to-noise (S/N) 100:1 in full scan mode • Acquisition rates of up to 50 Hz in both full scan and MS/MS modes • Ability to conduct MS/MS scans using a gradient or steps of collision energies within one scan event • Ability to statistically compare samples using principal component analysis (PCA) analysis, partial least square analysis, hierarchical clustering, and T-test capabilities The purpose of this sources sought notice is to conduct market research and identify potential sources of commercial products/services that satisfy the Government's anticipated needs. NIST is seeking information from sources that may be capable of providing the required system, and responses should include company information, equipment description, technical specifications, and performance capabilities.