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U.S. Department Of Energy·Ohio

TECHNOLOGY LICENSING OPPORTUNITY: Clathrate Therapeutics Platform

Closes 12/3/2026$200k – $5MRequest for Expression of Interest
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Description

The Clathrate Therapeutics Platform is a novel technology that enables controlled, localized delivery of therapeutic gases at the site of disease. This platform has the potential to unlock new commercial opportunities in areas where gas-based therapeutics have shown promise but faced delivery limitations. The technology uses a proprietary, controlled-release system designed to localize therapeutic gases at the intended treatment site, minimizing systemic exposure. The key advantages of this platform include localized delivery, controlled release, improved safety margin, platform versatility, development optimization, and partnership-ready architecture. The market applications for this technology include oncology therapeutics, cardiovascular and vascular medicine, neurology and neurodegenerative disease, regenerative medicine, and medical device and drug-device combination companies. • Localized delivery: Targets therapeutic gases to the intended site while minimizing systemic exposure. • Controlled release: Designed for sustained, tunable dosing under physiological conditions. • Improved safety margin: Aims to separate therapeutic effect from toxicity risk. • Platform versatility: Applicable across oncology, cardiovascular, neurological, and regenerative indications. • Development optimization: Supported by predictive modeling to guide dose and design decisions. • Partnership-ready architecture: Suitable for integration with drug-device combinations and existing treatment modalities.

Attached files

The solicitation documents live at the source — open the bid source above to download them.

Contact

Caleb Ledgerwood

[email protected]

Key dates

Opened
6/4/2026
Closes
12/3/2026

Last updated

Details

Type
Request for Expression of Interest
Industry
Healthcare and Medical Services
NAICS
325412
Solicitation №
S-195396

Budget estimate

$200,000 – $5,000,000

The budget for this opportunity is difficult to estimate because the document does not provide specific information on the licensing fees or royalties. However, based on the technology's potential to unlock new commercial opportunities in the pharmaceutical and medical device industries, the budget could be substantial. The licensing fees or royalties could range from a few hundred thousand dollars to several million dollars, depending on the terms of the licensing agreement and the commercial success of the technology. Factors that may influence the likely payment range include the technology's potential for widespread adoption, the competitive landscape, and the negotiating power of the parties involved.

AI estimate from the solicitation

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