HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to solicit applications for pilot projects to identify new druggable targets for pain within the understudied druggable proteome. Awards will support generation of preliminary data and/or tools around eligible understudied protein(s) listed in this NOFO. This NOFO is intended to jumpstart research on understudied proteins within the context of pain and pain management and provide applicants with sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins to identify new druggable targets for pain. Key aspects of this opportunity include: • Identifying new druggable targets for pain within the understudied druggable proteome • Generating preliminary data and/or tools around eligible understudied protein(s) • Jumpstarting research on understudied proteins within the context of pain and pain management • Providing sufficient funding to perform basic biochemical and/or biological work to further the characterization of understudied proteins • Focusing on the development of novel medications to treat all aspects of the opioid addiction cycle