NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)

This opportunity is for investigator-initiated, early phase, clinical trials of natural products, including botanicals, dietary supplements, and probiotics. The goal is to determine whether the natural product has a strong scientific premise to justify further clinical testing. The trials must be designed to provide information of high scientific utility and support decisions about further development or testing of the natural product. Key aspects of the job include: • Replicating the impact of the natural product on target engagement when used by humans • Assessing the association between the degree of impact on target engagement and functional or clinical outcomes in a patient population • Determining how to optimize the impact of the natural product on target engagement through examination of different doses or formulations • Combining the natural product with another treatment approach that is known to engage the same target • Studying the impact of the natural product in a target population that is more responsive.