NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated, early phase, clinical trials of natural products. The trials must be designed to provide information of high scientific utility and will support decisions about further development or testing of the natural product. The NOFO will provide up to three years of support for milestone-driven testing, and if milestones are achieved, up to 3 years of additional support may be awarded to replicate the impact of the natural product. • The opportunity is for early phase clinical trials of natural products, including botanicals, probiotics, and products marketed as dietary supplements. • The trials must have a strong scientific premise to justify further clinical testing. • The NOFO will provide support for up to 6 years, with the possibility of additional funding if milestones are achieved. • Applications are encouraged to design studies to determine how to optimize the impact of the natural product on target engagement. • The opportunity is open to various types of organizations, including nonprofits, institutions of higher education, and small businesses.