INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)

The National Institutes of Health (NIH) is seeking applications for the INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research. The purpose of this Notice of Funding Opportunity (NOFO) is to encourage Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven, and the total project period may not exceed five years. Some key points about this opportunity include: • The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. • The proposed research aims should be milestone-driven. • The total project period for an application submitted in response to this NOFO may not exceed five years. • This NOFO provides support for up to two years (R61 phase) for preliminary/developmental/planning studies, followed by possible transition to clinical trial support (R33) of up to three years. • The NIH encourages inquiries concerning this funding opportunity and welcomes the opportunity to answer questions from potential applicants.