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U.S. National Institutes of Health·United States of America

Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)

Closes 1/11/2027$500k – $1.2MGrants Notice
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Description

The National Cancer Institute (NCI) is issuing a Request for Applications (RFA) to fund a Glioblastoma Therapeutics Network (GTN) under a U19 Cooperative Agreement. The network will consist of up to four cross‑cutting research teams that will advance novel or repurposed therapeutic agents for adult glioblastoma (GBM) from late pre‑clinical work through Phase 0/1 pilot clinical trials. Successful candidates must demonstrate the ability to develop agents that cross the blood‑brain barrier, conduct IND‑enabling studies, and initiate early‑phase human testing. The award provides up to $700,000 per U19 award (total estimated funding $4.4 M) and expects strong collaboration with NCI program staff, data sharing, and adherence to NIH policies. Applications are limited to one per institution and are open to a broad range of U.S. entities (non‑profits, for‑profit, academic, government, etc.). The submission window opens 1 Sept 2026 and closes 11 Jan 2027.

Attached files

Contact

NCI GTN Program(Scientific/Research Contact)

[email protected]

(240) 276-5922

Key dates

Opened
9/17/2025
Closes
1/11/2027
Projected award
3/5/2027
Duration
4 years

Last updated

Details

Type
Grants Notice
Industry
Healthcare and Medical Services
NAICS
541714
Solicitation №
RFA-CA-27-005

Budget estimate

$500,000 – $1,200,000

The NOFO lists an award ceiling of $700,000 per U19 award and a total estimated funding pool of $4,400,000 for four awards. Assuming each award could range from the minimum feasible funding (≈$500,000) to the ceiling, a typical award might be between $500k and $1.2 M, depending on the scope of the proposed network, the number of therapeutic candidates, and the extent of clinical trial activities. Larger, multi‑agent projects with extensive IND work could approach the upper bound, while more focused, single‑agent efforts may sit near the lower end.

AI estimate from the solicitation

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