JPEO-CBRND EB New Approach Methods (NAMs) RFI

The Joint Program Executive Office for Chemical, Biological, Radiological, and Nuclear Defense, Enabling Biotechnologies (JPEO-CBRND-EB) is seeking information on New Approach Methods (NAMs) for the development of Medical Countermeasures (MCMs) for Chemical, Biological, Radiological, and Nuclear (CBRN) threats. The NAMs should utilize computational modeling, artificial intelligence, and machine learning to augment or replace animal-based non-clinical testing in drug development. The requested information includes descriptions of the model system, test, or capability, its workings, and how it is intended to reproduce key features of CBRN threat exposure, biological responses, or MCM dose, efficacy, and toxicology. • Recapitulation of in-vivo CBRN threat exposure, disease states, and pathologies • NAM approaches to support or replace key nonclinical toxicology, pharmacology, or efficacy studies used to support MCM development • NAM approaches that inform human estimated dose • Use of artificial intelligence and machine learning capabilities to augment or improve NAMs, accelerate toxicology studies, or other in-vivo studies