Blood Sample Protein Measurement Analysis

The Washington DC VA Medical Center is conducting a prospective biospecimen collection and clinical data repository study to generate reproducible, high-quality proteomic data from longitudinal plasma specimens. The goal of this study is to identify novel protein signatures that reflect tumor biology in real-time, enabling earlier detection of therapeutic resistance and more personalized treatment sequencing. The contractor will be responsible for receiving coded frozen plasma aliquots, performing SomaScan assay processing, and returning standardized proteomic data output and quality documentation to the VA study team. The contractor must have an established, analytically validated, CLIA-certified plasma proteomic assay platform capable of processing coded research specimens in defined study batches. Some key points to consider: • The contract period of performance will be a base year with a one-year option period. • The contractor shall receive, thaw, and prepare plasma samples for SomaScan assay processing. • The contractor shall perform SomaScan assay processing on all submitted samples, including standard assay-level quality control. • The contractor shall return proteomic data output in standard ADAT file format, accompanying quality assurance documentation, and any unused sample material to the VA study team. • The contractor shall process samples in study batches as submitted by the VA, with an anticipated minimum batch size of approximately 40 samples per submission.