TECHNOLOGY LICENSING OPPORTUNITY: Multidimensional Mass Fingerprinting for Antibiotic-Resistant Bacteria (MultiScan-AR)

The Los Alamos National Laboratory is offering a technology licensing opportunity for Multidimensional Mass Fingerprinting for Antibiotic-Resistant Bacteria (MultiScan-AR). This technology is a multidimensional tandem mass spectrometry technique that can identify pathogens and their antibiotic-resistance profiles in minutes to hours. The technique works with existing mass spectrometry instruments and can be used in various settings, including clinical diagnostics, point-of-care testing, and public health and biosurveillance. The advantages of this technology include its ability to deliver pathogen identification and antibiotic-resistance information quickly, distinguish closely related bacterial strains, and work with existing instruments. The market applications for this technology include clinical diagnostics, point-of-care testing, public health and biosurveillance, field-deployable medicine, analytical instrument platforms, and antimicrobial research. • The technology is built around a multidimensional tandem mass spectrometry technique that interrogates lysed microbial samples with a level of granularity beyond conventional strain-typing instruments. • The technique layers onto established platforms such as benchtop biotyping analyzers and portable field spectrometers. • The resulting data set is intentionally dense, combining precursor-mass and product ion-level measurements in both ionization modes. • A purpose-built processing pipeline renders the data as a single multidimensional mass fingerprint for interpretation.