Tuberculosis Research Units (P01 Clinical Trial Optional)

The National Institutes of Health (NIH) is seeking applications for the establishment of multidisciplinary Tuberculosis (TB) Research Units (TBRUs) to improve understanding of Mycobacterium tuberculosis (Mtb)-host interactions. The TBRUs will operate as a collaborative network to characterize the roles of bacterial and host heterogeneity on infection outcomes and disease progression, and define bacterial and host determinants relevant to Mtb establishment, dissemination, and disease stage. Key aspects of this opportunity include: • The establishment of multidisciplinary research units to study TB • The focus on characterizing the roles of bacterial and host heterogeneity on infection outcomes and disease progression • The definition of bacterial and host determinants relevant to Mtb establishment, dissemination, and disease stage • The collaborative network of TBRUs to improve understanding of Mtb-host interactions • The use of the P01 activity code for this Notice of Funding Opportunity (NOFO)