Viral INfections in the Young Lung- The VINYL Clinical Consortium (UG3/UH3 Clinical Trial Optional)

The National Heart, Lung and Blood Institute (NHLBI) seeks to support a consortium to phenotype 0-2 year old children with severe viral lower respiratory tract infections (LRTI) with follow up until pre-school age for pulmonary sequelae. The objective of this program is to create a consortium of clinical sites that will perform deep phenotyping in 1500 babies, infants, and toddlers with viral LRTI and hospitalized with acute bronchiolitis, pneumonia, and/or pediatric acute respiratory distress syndrome (PARDS). Key aspects of the job include: • Deep phenotyping of 0-2 year old children with severe viral LRTI • Follow-up until pre-school age for pulmonary sequelae • Longitudinal follow-up of participants after discharge using electronic health records and questionnaires • Assessment of respiratory status at age 4-5 years to elucidate pulmonary outcomes from early viral LRTI • Investigation of neurocognitive and general development, and sleep during follow-up