Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)

The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to address adverse sequelae of cancer therapies that persist and become chronic comorbidities or develop as delayed posttreatment effects. This FOA supports basic, translational, and clinical research projects that seek to identify the mechanisms of therapy-induced adverse sequelae, clinically characterize the adverse sequelae, or translate the mechanistic understanding into therapeutic approaches to prevent or minimize the development of long-term sequelae. Research projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping to identify and validate clinical endpoints for future use in clinical trials that will evaluate the efficacy of interventions designed to prevent or reduce specific adverse sequelae. • The FOA will support research projects that address adverse sequelae of cancer therapies. • The research projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping. • The FOA will support basic, translational, and clinical research projects. • The goal of the research projects is to identify the mechanisms of therapy-induced adverse sequelae, clinically characterize the adverse sequelae, or translate the mechanistic understanding into therapeutic approaches. • The research projects should aim to prevent or minimize the development of long-term sequelae.