Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. The research should focus on developing or refining causal hypotheses, including biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that contribute to human behaviors and oral-systemic health outcomes. The goal of the research is to provide a better understanding of the underlying mechanisms of oral-systemic health and to develop effective interventions to prevent, treat, and manage dental, oral, and craniofacial diseases and related conditions. • The research should be focused on human behaviors and their impact on oral-systemic health. • The research should aim to develop or refine causal hypotheses. • The research should be innovative and have the potential to lead to significant advances in the field. • The research should be conducted by a multidisciplinary team with expertise in relevant areas, such as dental, oral, and craniofacial health, and behavioral, biological, and social sciences. • The research should have the potential to lead to the development of effective interventions to prevent, treat, and manage dental, oral, and craniofacial diseases and related conditions.