Sources Sought Notice - Risk–Benefit Assessment of Stopping Antibiotics in Rapid Respiratory Viral Panel (RVP) Positive Inpatients with Non-Severe Community-Acquired Pneumonia

The Department of Health and Human Services (HHS) is seeking information from qualified business organizations to conduct a large-scale, pragmatic randomized trial evaluating the continued administration of antibiotics for patients with non-severe pneumonia and testing positive for a respiratory viral pathogen. The trial aims to establish the risks and benefits of antibiotics for these patients. The contractor will be responsible for conducting the trial, enrolling patients, collecting data, and analyzing results. The project is expected to last 39 months, including a 12-month preparatory period, 18-month intervention, and 9 months for post-intervention data analysis. • The contractor must have expertise in large-scale pragmatic trials, electronic health record-based interventions, and antibiotic stewardship. • The contractor must have experience in recruiting patients, managing data, and communicating with healthcare providers. • The contractor must have a strong plan for recruitment, data collection, and analysis. • The contractor must have experience in performing multiple tasks in parallel while meeting deliverable timelines. • The contractor must have expertise in project management, trial conduct, and federal government requirements.