synthesis of prodrug analogs and cyclopentane peptide nucleic acid (PNA) precursors

The National Institutes of Health (NIH) is seeking a contractor to synthesize prodrug analogs and cyclopentane peptide nucleic acid (PNA) precursors. The contractor will be required to provide synthesis scale-up, custom synthesis, purification, and characterization of optimized lead compounds and specialized precursor materials. These materials are not commercially available and require specialized synthetic expertise and production capabilities to generate quantities sufficient for continued preclinical evaluation. The key aspects of this opportunity include: • Synthesis of prodrug analogs and cyclopentane peptide nucleic acid (PNA) precursors • Custom synthesis, purification, and characterization of optimized lead compounds and specialized precursor materials • Materials are not commercially available and require specialized synthetic expertise and production capabilities • The contractor will be required to provide quantities sufficient for continued preclinical evaluation