Description
The Biomedical Advanced Research and Development Authority (BARDA) is seeking information on technical capabilities, infrastructure, prior experience, and recommended approaches for the AI-enabled discovery of broad-spectrum small-molecule inhibitors for filoviruses. The goal is to identify organizations with capabilities in artificial intelligence (AI) for application in the discovery and advancement of broad-spectrum, small-molecule therapeutics targeting filoviruses. Respondents are requested to address BARDA's interest in the discovery and advancement of potent, safe, broad-spectrum, small-molecule inhibitors of filoviruses. Some key areas of interest include:
• AI-driven design
• In vitro verification of hits
• Early preclinical proof-of-concept evaluation
• Teaming arrangements or partnerships to address the full scope of capabilities
• Experience and/or partnerships with small animal models and early preclinical development for viral pathogens
• Approaches to model improvement/optimization and iterative design cycles.