Single Source Competition for Continuation of Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)

The National Institutes of Health is seeking a single-source competition for the continuation of the Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers. The purpose of this solicitation is to support the completion of the scientific objectives of the ongoing DISCOVERY clinical consortium, a multi-center longitudinal study conducted across 19 clinical sites to identify risk factors and biological mechanisms driving progression to youth-onset type 2 diabetes. The current Biostatistics Research Center serves as the consortium's central coordinating center, and this solicitation aims to support the preservation of the integrity of the longitudinal dataset. Key aspects of this opportunity include: • The study is actively recruiting and following early pubertal youth at high risk for the disease with longitudinal follow-up currently underway. • The current Biostatistics Research Center has established a robust infrastructure and standardized processes required to support the study. • The purpose of this single-source solicitation is to support completion of the scientific objectives of the ongoing DISCOVERY clinical consortium. • The estimated funding for this opportunity is $35,000,000.