Cellular and Molecular Biology of Complex Brain Disorders (R01 Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) encourages research on the biology of high-confidence risk factors associated with complex brain disorders. The focus is on the intracellular, transcellular, and circuit substrates of neural function. Studies may be either hypothesis-generating or hypothesis-testing in design and may utilize in vivo, in situ, or in vitro experimental paradigms. The resulting paradigms, component pathways, and biological processes should be disseminated with sufficient detail to enrich common and/or federated data resources. • The opportunity is for research on complex brain disorders with a focus on the biology of high-confidence risk factors. • The research should aim to elucidate the neurobiological impact of individual or combined risk factor(s). • The opportunity is not for modeling disorders but instead for understanding the fundamental biology of risk factors and their relationships within defined biological processes. • The research design can incorporate behavioral paradigms and outcome measures but is not required to do so.