BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)

The National Institutes of Health (NIH) is soliciting applications for the BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain. This program aims to support the development of computational tools for understanding dynamic brain circuits, which will be made broadly accessible to the greater research community. The tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinson's disease and major depressive disorder. • The program will support applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning the scale of neurons and firing rates. • Collaborative investigations combining expertise in mechanistic, interpretable and predictive models of neural dynamics, and neural circuit function, will be encouraged. • The program will utilize the R01 activity code and will provide support for the development of computational tools, theories, models, and methods for understanding brain function. • The tools developed will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics.